Karen Vaccaro is an actress, known for Just Visiting, Stir of Echoes, The Opera Lover, and U.S. Marshals. Other film credits include Unconditional Love, U.S. Marshals, I Do, Stuck on You!, and Waitress!

Theatre credits include her Broadway debut as Sadie in The Rise and Fall of Little Voice (Neil Simon Theatre); and regionally, as Freddy in Buena Vista (Steppenwolf Theatre) and Helen in Sin (Goodman Theatre).