Jennifer Tilly has appeared onstage in Tartuffe and Boy’s Life (L.A. Theatre); and Baby with the Bathwater and The Woolgatherer (L.A. Public Theatre). She received Drama-Logue Awards for her work in Vanities and for her performance in One Shoe Off, for which she also won a TheatreWorld Award for Outstanding Newcomer (Joseph Papp Theatre). 

She received both an Academy Award nomination and an American Comedy award nomination for her role as Olive in Woody Allen’s Bullets over Broadway. Other film credits include Liar, Liar; Bound; The Muse; Relax; It’s Just Sex; Stuart Little; The Getaway; Made in America; Bride of Chucky; and The Fabulous Baker Boys. 

On television, she starred in the miniseries, Bella Mafia, FOX's Key West and had a recurring role as Garry’s girlfriend on The Garry Shandling Show.